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Able Signal LLC, Whitehead Institute for Biomedical Research, Geneva University Hospital, Illumina, University of South Florida, Genesis Research & Development Corp, Via Lachia Bioscience


Perry Sandstrom, an engineer at the University of Wisconsin, Madison, and the founder of Able Signal LLC, has received US Patent No. 6,545,758, “Microarray detector and synthesizer.” The patent describes spatial light modulators, including micromirror systems, that are used to synthesize and read microarrays.


David Sabatini of the Whitehead Institute for Biomedical Research, has been awarded US. Patent No. 6,544,790, “Reverse transfection method.” The patent, which MIT has exclusively licensed to Sabatini's cell-based microarray company Akceli, covers a method to introduce select DNA sequences into cells and arrays using reverse transfection.


Jacques Schrenzel of Geneva University Hospital and Jonathan Hibbs, formerly of the University of Albany, have received US Patent No. 6,544,777, “Non-cognate hybridization system.” The system is used to probe for nucleic acids of unknown target sequences. The results can point to specific diagnoses, such as infections, autoimmune diseases, or neoplasm; or more general diagnoses such as sepsis and tumor necrosis.


Illumina of San Diego has received US Patent No. 6,544,732, “Encoding and decoding of array sensors utilizing nanocrystals.” The patent covers assays that encode and decode nanocrystal microspheres.


David Fries, of the University of South Florida, has received US Patent No. 6,544,698, “Maskless 2-D and 3-D pattern generation photolithography.” The patent describes a reconfigurable photolithography system for microarray synthesis, which uses micromirrors in order to direct light onto specific spots on a photoreactive substrate. The pattern is designed and stored on a computer, and the micromirrors that direct the system are computer controlled.


Genesis Research & Development Corp. of Parnell, New Zealand, and Via Lachia Bioscience, of Auckland, New Zealand, have received US Patent No. 6,544,772, “Polynucleotides, materials incorporating them, and methods for using them.” The patent describes polynucleotide sequences, as well as probes, primers, and other genetic constructs of these sequences, from the bacterial species Lactobacillus rhamnosus.

The Scan

Just Breathing

A new analysis suggests that most Mycobacterium tuberculosis is spread by aerosols from breathing, rather than by coughing, the New York Times reports.

Just Like This One

NPR reports that the World Health Organization has hired a South African biotech company to recreate mRNA vaccine for SARS-CoV-2 that is similar to the one developed by Moderna.

Slow Start

The Wall Street Journal reports that Biogen's Alzheimer's disease treatment had revenues for July through September that totaled $300,000.

Genome Research Papers on Cancer Chromatin, Splicing in the Thymus, Circular RNAs in Cancer

In Genome Research this week: analysis of bivalent chromatin sites, RBFOX splicing factors' role in thymic epithelial cells, and more.