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Able Signal LLC, Whitehead Institute for Biomedical Research, Geneva University Hospital, Illumina, University of South Florida, Genesis Research & Development Corp, Via Lachia Bioscience


Perry Sandstrom, an engineer at the University of Wisconsin, Madison, and the founder of Able Signal LLC, has received US Patent No. 6,545,758, “Microarray detector and synthesizer.” The patent describes spatial light modulators, including micromirror systems, that are used to synthesize and read microarrays.


David Sabatini of the Whitehead Institute for Biomedical Research, has been awarded US. Patent No. 6,544,790, “Reverse transfection method.” The patent, which MIT has exclusively licensed to Sabatini's cell-based microarray company Akceli, covers a method to introduce select DNA sequences into cells and arrays using reverse transfection.


Jacques Schrenzel of Geneva University Hospital and Jonathan Hibbs, formerly of the University of Albany, have received US Patent No. 6,544,777, “Non-cognate hybridization system.” The system is used to probe for nucleic acids of unknown target sequences. The results can point to specific diagnoses, such as infections, autoimmune diseases, or neoplasm; or more general diagnoses such as sepsis and tumor necrosis.


Illumina of San Diego has received US Patent No. 6,544,732, “Encoding and decoding of array sensors utilizing nanocrystals.” The patent covers assays that encode and decode nanocrystal microspheres.


David Fries, of the University of South Florida, has received US Patent No. 6,544,698, “Maskless 2-D and 3-D pattern generation photolithography.” The patent describes a reconfigurable photolithography system for microarray synthesis, which uses micromirrors in order to direct light onto specific spots on a photoreactive substrate. The pattern is designed and stored on a computer, and the micromirrors that direct the system are computer controlled.


Genesis Research & Development Corp. of Parnell, New Zealand, and Via Lachia Bioscience, of Auckland, New Zealand, have received US Patent No. 6,544,772, “Polynucleotides, materials incorporating them, and methods for using them.” The patent describes polynucleotide sequences, as well as probes, primers, and other genetic constructs of these sequences, from the bacterial species Lactobacillus rhamnosus.

The Scan

US Supports Patent Waivers

NPR reports that the Biden Administration has announced its support for waiving intellectual property protections for SARS-CoV-2 vaccines.

Vaccines Versus Variants

Two studies find the Pfizer-BioNTech SARS-CoV-2 vaccine to be effective against viral variants, and Moderna reports on booster shots to combat variants.

CRISPR for What Ails You

The Wall Street Journal writes that CRISPR-based therapies could someday be used to treat common conditions like heart attacks.

Nature Papers Review Integration of Single-Cell Assay Data, Present Approach to Detect Rare Variants

In Nature this week: review of ways to integrate data from single-cell assays, and more.