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3M Innovative Properties, Tufts College, Klaus Abraham-Fuchs, Affymetrix

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3M Innovative Properties of St. Paul, Minn., received US Patent No. 6,482,638, “Heat-relaxable substrates and arrays.” The patent covers a method for manufacturing high-density arrays on heat-relaxable substrates, such as an oriented polymer, and the systems for relaxing them using electromagnetic energy.

The Trustees of Tufts College of Medford, Mass., received US Patent No. 6,482,593 for “Fiber optic biosensor for selectively detecting oligonucleotide species in a mixed fluid sample.” The patent is for a system of optical biosensors, apparatus, and methods for selectively detecting at least one complementary oligonucleotide target species in a fluid sample containing a mixture of different oligonucleotide fragments. One preferred embodiment of the biosensor is as a unitary fiber optic array having species of single stranded nucleic acid disposed as individual deposits in aligned organization upon multiple strand end faces at differing spatial positions on the distal array end surface.

Klaus Abraham-Fuchs of Erlangen, Germany, et al., received US Patent No. 6,484,104 for “Network for evaluating data obtained in a biochip measurement device.” A disposable biochip is provided, which contains a patient sample with multiple biomolecular markers, as well as a biochip identifier that characterizes the biochip. The biochip is inserted into a point of care test device, which reads the biochip identifier. The point of care test device transmits the data characterizing the biochip to a remote server having access to a data bank in which a large number of measurement protocols are stored, and which selects one of the measurement protocols for testing the sample based on the transmitted data characterizing the biochip. The measurement protocol is transmitted back to the point of care test device via the data link, where the sample is tested using the measurement protocol. The test results are evaluated in an expert system, and a diagnostic result is displayed at the point of care test device.

Affymetrix of Santa Clara, Calif., received US Patent No. 6,484,183, “Method and system for providing a polymorphism database.” The patent is for methods for organizing information relating to the study of polymorphisms. A database model is provided that interrelates information about one or more subjects from whom samples are extracted, primers used in extracting the DNA from the subjects, the samples themselves, experiments done on samples, and particular oligonucleotide probe arrays used to perform experiments, about analysis procedures performed on the samples, and about analysis results. The model is readily translatable into SQL.

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