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3m Innovative Properties Company, Genicon Sciences, Large Scale Proteomics, Agilent Technologies, The Center for the Application of Molecular Biology to International Agriculture, Rosetta Inpharmatics


3m Innovative Properties Company has received US Patent No. 6,714,675, Autogrid analysis. The patent describes a method and apparatus to identify the positions of elements of a grid, as well as the orientation of the grid. The method can be used for multi-sided grids, and the addresses can be used for analytical procedures that are directed to individual grid elements.

Genicon Sciences (which was acquired by Invitrogen in July 2003), has obtained US Patent No. 6, 714, 299, “Use of light scattering particles in design, manufacture, and quality control of small volume instruments, devices, and processes.” The patent describes Genicon’s Resonance Light Scattering technology, which incolves the use of these light scattering particles in design, manufacture and quality control of microscale devices, as well as the analysis of the substrate for these particles. See BAN 10-19-01.

Large Scale Proteomics, a subsidiary of Large Scale Biology, has received US Patent No. 6, 713,309, “Micro-arrays and their manufacture.” These are prepared using a separate fiber for each compound, and are bundled to form a thin microarray glued to a backing.

Agilent Technologies has received US Patent No. 6,713,262, “Methods and compositions for high throughput identification of protein/nucleic acid binding pairs.” The patent describes methods to identify protein-nucleic acid binding pairs in a high-throughput manner, using a nucleic acid probe array. The array is hybridized to target nucleic acids, then a protein population is added to it. The target nucleic acid-protein complexes are then detected. The patent also describes systems and kits for these arrays.

The Center for the Application of Molecular Biology to International Agriculture, of Black Mountain, Australia, has received US Patent No. 6,713,258, “Methods for genotyping by hybridization analysis.” The invention involves methods for determining an organism’s genotype and establishing the relationship between organisms in a species using hybridization analysis. It includes addressable arrays with panels of nucleic acid molecules to distinguish between different nucleic acid samples. The products of this panel are hybridized with labeled nucleuc acids to determine the genotype of an organism.

Rosetta Inpharmatics, (now a Merck subsidiary) has received US Patent No. 6,713,257,”Gene discovery using microarrays.” The patent relates to methods and systems to identify and characterize genes using microarrays. In particular it involves ways to map gene expression to the structure of the genome.


The Scan

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.

SpliceVault Portal Provides Look at RNA Splicing Changes Linked to Genetic Variants

The portal, described in Nature Genetics, houses variant-related messenger RNA splicing insights drawn from RNA sequencing data in nearly 335,700 samples — a set known as the 300K-RNA resource.

Automated Sequencing Pipeline Appears to Allow Rapid SARS-CoV-2 Lineage Detection in Nevada Study

Researchers in the Journal of Molecular Diagnostics describe and assess a Clear Labs Dx automated workflow, sequencing, and bioinformatic analysis method for quickly identifying SARS-CoV-2 lineages.

UK Team Presents Genetic, Epigenetic Sequencing Method

Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.