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You Want the Good News, or the Bad News?


According to researchers, children who have survived cancer are at increased risk of developing secondary tumors, says Reuters' Frederik Joelving. Gregory Armstrong from St. Jude Children's Research Hospital tell Reuters that skin cancers — which could be considered relatively harmless under normal circumstances — appear to be early warning signs of more aggressive disease in such kids. In a new study published by Armstrong and his team in the Journal of Clinical Oncology, the researchers found that such skin cancers could be a biomarker of risk in such patients, Joelving says. The study tracked about 14,000 kids who had survived cancer for at least five years, for up to 38 years after diagnosis — five percent developed a new cancer, Joelving says. The risk for a third cancer was 12 percent in patients who had already beaten cancer twice, and the risk was increased for patients who had received radiation as part of their treatment, he adds. Armstrong says this study makes the case for keeping a closer eye on survivors of childhood cancer, and that such patients must be diligent about seeing their doctors. The good news, he adds, is that many more children are being cured of cancer now than they were 50 years ago.

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.