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You Give Me Fever


It seems that tumors hate the heat, says New Scientist's Ferris Jabr. In a new study published in PNAS, researchers at the University of Amsterdam show that high temperatures undercut a tumor's ability to fight off cancer drugs by denaturing the BRCA2 protein that repairs breaks cancer cells' DNA, Jabr says. This suggests to researchers that the right combination of heat and drugs may improve the effectiveness of cancer therapy. "Cells have DNA repair pathways because they constantly accumulate DNA damage, so fixing it is good for normal cells, but DNA repair allows cancer cells to resist therapy that does DNA damage," study co-author Roland Kanaar tells Jabr. "The researchers suggest that hyperthermia would make an excellent ally for anti-cancer drugs that impair DNA-repair enzymes, such as PARP-1 inhibitors," Jabr adds.

The Scan

Not Yet a Permanent One

NPR says the lack of a permanent Food and Drug Administration commissioner has "flummoxed" public health officials.

Unfair Targeting

Technology Review writes that a new report says the US has been unfairly targeting Chinese and Chinese-American individuals in economic espionage cases.

Limited Rapid Testing

The New York Times wonders why rapid tests for COVID-19 are not widely available in the US.

Genome Research Papers on IPAFinder, Structural Variant Expression Effects, Single-Cell RNA-Seq Markers

In Genome Research this week: IPAFinder method to detect intronic polyadenylation, influence of structural variants on gene expression, and more.