Skip to main content
Premium Trial:

Request an Annual Quote

WUSTL, UC Boulder to Conduct Metagenomics Studies of Inflammatory Bowel Disease

NEW YORK (GenomeWeb News) – Genomics researchers at Washington University in St. Louis and at the University of Colorado at Boulder will work as partners with the Crohn’s and Colitis Foundation of America to study how microbes in the human gut contribute to inflammatory bowel disease, the foundation said today. 
 
The foundation’s Gut Microbiome Initiative will use metagenomic sequencing and informatics methods to develop new molecular and bioinformatics tools that can be used in the development of cures for chronic digestive diseases.
 
Crohn’s disease and ulcerative colitis, collectively referred to as IBD, affect over 1.4 million Americans, CCFA said in a statement.
 
Jeffrey Gordon, director of Washington University’s Center for Genome Sciences, will serve as principal investigator on the project, which will focus on identical and fraternal twins and their mothers first, and then on IBD patients.
 
Gordon said in a statement that "knowing how to rapidly and accurately define the nature and operations of the gut microbiome should help investigators develop new insights about the mechanisms that lead to IBD, better ways to diagnose and categorize IBD, new therapeutic approaches, and ultimately, new ways to prevent these disorders in susceptible individuals.”
 
University of Colorado’s Rob Knight will lead a group developing data-mining and statistical and visualization tools that can handle the “complex and massive datasets” the genomics research will generate.
 
The tools and the gut microbiome datasets will be made publicly available in order to be of use to other researchers, CCFA said.
 
CCFA also said it expects the efforts will help in the development of new molecular diagnostics.
 

The Scan

Octopus Brain Complexity Linked to MicroRNA Expansions

Investigators saw microRNA gene expansions coinciding with complex brains when they analyzed certain cephalopod transcriptomes, as they report in Science Advances.

Study Tracks Outcomes in Children Born to Zika Virus-Infected Mothers

By following pregnancy outcomes for women with RT-PCR-confirmed Zika virus infections, researchers saw in Lancet Regional Health congenital abnormalities in roughly one-third of live-born children.

Team Presents Benchmark Study of RNA Classification Tools

With more than 135 transcriptomic datasets, researchers tested two dozen coding and non-coding RNA classification tools, establishing a set of potentially misclassified transcripts, as they report in Nucleic Acids Research.

Breast Cancer Risk Related to Pathogenic BRCA1 Mutation May Be Modified by Repeats

Several variable number tandem repeats appear to impact breast cancer risk and age at diagnosis in almost 350 individuals carrying a risky Ashkenazi Jewish BRCA1 founder mutation.