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The Whole Enchilada


Researchers at the Broad Institute and Dana-Farber Cancer Institute have uncovered the most complete multiple myeloma genome to date, according to a Broad press release. The researchers sequenced 38 cancer samples for their study, which appears in Nature, and the result unveils genes that have never before been associated with cancer as well as new mutations or triggers for cancer development that could lead to new avenues for study or possibly new treatments, the Broad release says. One finding of immediate clinical importance is the discovery of mutations in the BRAF gene in some multiple myeloma patients — something that has never been seen with this disease before, but is known to be active in other cancers like melanoma and colon cancer. Drugs are now being tested to target BRAF mutations in patients with melanoma and, although further studies are needed, drugs that inhibit BRAF could also be effective in patients with multiple myeloma, the Broad release adds.

The Scan

Study Reveals Details of SARS-CoV-2 Spread Across Brazil

A genomic analysis in Nature Microbiology explores how SARS-CoV-2 spread into, across, and from Brazil.

New Study Highlights Utility of Mutation Testing in Anaplastic Thyroid Cancer

Genetic mutations in BRAF and RAS are associated with patient outcomes in anaplastic thyroid carcinoma, a new JCO Precision Oncology study reports.

Study Points to Increased Risk of Dangerous Blood Clots in COVID-19 Patients

An analysis in JAMA Internal Medicine finds that even mild COVID-19 increases risk of venous thromboembolism.

Y Chromosome Study Reveals Details on Timing of Human Settlement in Americas

A Y chromosome-based analysis suggests South America may have first been settled more than 18,000 years ago, according to a new PLOS One study.