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Whitehead s PathBLAST Shows Conserved Protein Interaction Networks in PNAS Study

NEW YORK, Sept. 26 (GenomeWeb News) - Whitehead Institute scientists published a study in the Proceedings of the National Academy of Sciences this week in which they used a protein interaction network mapping program called PathBLAST to compare the interaction networks predicted by the entire genomes of S. cerevisiae (yeast) and the bacterium H. pylori.


PathBLAST, developed by Whitehead fellows Trey Ideker and Brent Stockwell, uses algorithms to represent chemical structures.


The study showed that both organisms had two similar pathways-one for catalyzing DNA replication and one involved in protein degradation-and that in both organisms these two pathways were integrated as a single network.


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