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Where Are They Now?: Jun 1, 2003

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A year ago, GT reached you with its “Mass Spec Special” cover story. We looked at the instruments available and used feedback from a reader survey to help break down which mass spec was right for which type of user. A year later, the mass spec field continues to heat up. As our cover story in this issue shows, Fourier transform mass spec is becoming the latest trend, and hybrid instruments are rising up as well. (See p. 34)

We also looked at the DNA sequencer scandal last year — the lawsuit launched by MJ Research against Applied Biosystems and others had just been unsealed. Since then, the lawsuit has moved forward, although filings of motions have considerably slowed the pace at which it was originally estimated to take place. We also reported in the April ’03 issue that Henry Huang, whom MJ Research claims actually invented the four-color DNA sequencer, filed his own lawsuit against ABI and the patent owners.

Last June, GT checked in on Bruce Roe, head of the University of Oklahoma’s genome center. Roe’s lab expects to move as soon as this coming academic year into the brand new Peggy and Charles Stephenson Research and Technology Center, built for genomics and computer science, among other technology-based disciplines.

The Scan

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.

TB Resistance Insights Gleaned From Genome Sequence, Antimicrobial Response Assays

Researchers in PLOS Biology explore M. tuberculosis resistance with a combination of sequencing and assays looking at the minimum inhibitory concentrations of 13 drugs.

Mendelian Disease Genes Prioritized Using Tissue-Specific Expression Clues

Mendelian gene candidates could be flagged for further functional analyses based on tissue-specific transcriptome and proteome profiles, a new Journal of Human Genetics paper says.

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.