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What's Taking So Long?

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A recent paper published in Nature might provide the answer to those who wonder why we haven't cured cancer yet, blogger ERV says. The researchers did complete genome sequencing of prostate cancer tumors from seven patients with advanced or aggressive disease in order to identify possible ways to treat patients. "Yeah, it's fishing, but they were going to learn something," ERV says. "I figured genomes got pretty messy in tumors, but I don't think I fully comprehend the magnitude of the chromosomal train-wreck of 'prostate cancer'." The researchers found an average of about 108 chromosomal abnormalities in the tumors, ERV says. One patient had 213 abnormalities. "And we aren't talking a mutation here, a tiny deletion there — we are talking huge chunks of DNA in the wrong place," ERV adds. "And people wonder why we haven't cured 'cancer' yet."

The Scan

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.

Rett Syndrome Mouse Model Study Points to RNA Editing Possibilities

Investigators targeted MECP2 in mutant mouse models of Rett syndrome, showing in PNAS that they could restore its expression and dial down symptoms.

Investigators Find Shared, Distinct Genetic Contributors to Childhood Hodgkin Lymphoma

An association study in JAMA Network Open uncovers risk variants within and beyond the human leukocyte antigen locus.

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.