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What's in The Cancer Genome Atlas?


With cancer researchers collecting more and more information on mutations, epigenetics, gene expression, and clinical features associated with different cancers, where does the information go? The data collected by large international groups like The Cancer Genome Atlas and the International Cancer Genome Consortium gets put into databases that are accessible to the public and searchable in various ways, says The Scientist's Carina Storrs. She has tips for researchers looking to use the information in these databases to help in their work.

Both groups' data portals allow for searches on mutation and expression data on specific genes, so that might be a good place to start, Storrs says. Or, there's also the possibility of searching through information on all known genes or pathways implicated in a certain tumor type. "Both ICGC and TCGA data are publicly available, but note that they have already been processed: sequences have been confirmed by various techniques, and patient-identifying information, such as the presence of germline SNPs, has been removed," Storrs says. Researchers can also search for gene drivers in various tumor types, frequency of certain mutations, or the functional impact of a given mutation.

Various universities and research centers, like Memorial Sloan-Kettering Cancer Center, also have their own cancer genomics databases, which can also be used as a starting point for research, Storr adds.

The Scan

More Boosters for US

Following US Food and Drug Administration authorization, the Centers for Disease Control and Prevention has endorsed booster doses of the Moderna and Johnson & Johnson SARS-CoV-2 vaccines, the Washington Post writes.

From a Pig

A genetically modified pig kidney was transplanted into a human without triggering an immune response, Reuters reports.

For Privacy's Sake

Wired reports that more US states are passing genetic privacy laws.

Science Paper on How Poaching Drove Evolution in African Elephants

In Science this week: poaching has led to the rapid evolution of tuskless African elephants.