A.I run an academic core sequencing lab. Previously, we operated two ABI 3700 sequencers that were purchased primarily with institutional funds. Last year, we upgraded to two ABI 3730/3730xl sequencers but chose to lease the instruments rather than purchase outright. This move has more than paid for itself and we are enjoying substantial improvements in quality, read length, speed, and reliability. At the same time, our reagents costs have dropped significantly, allowing overall costs to users to drop.