This Week in NEJM


In NEJM this week, researchers in Germany and Ireland report on a study on the links between chemoresistance in advanced colorectal cancer and function of the genes TFAP2E and DKK4. Alterations in TFAP2E are common in several human cancers, and DKK4 — a potential downstream target of TFAP2E — has been implicated in resistance to chemotherapy, the team says. For this study, the researchers analyzed the expression and function of TFAP2E in colorectal cancer cell lines and in patients with the disease.

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The London School of Economics' Daniele Fanelli argues at the Proceedings of the National Academy of Sciences that the reproducibility crisis in science isn't as dire as some say.

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