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This Week in Lancet Oncology: Apr 5, 2012


In Lancet Oncology this week, researchers in the US and Europe report a study on the associations between endometriosis and the risk for certain subtypes of ovarian cancer. The team analyzed data from 13 ovarian cancer case-control studies — a total of 7,911 women with invasive ovarian cancer and 13,226 controls. The researchers found that self-reported endometriosis was associated with a significantly increased risk of clear-cell, low-grade serous, and endometrioid invasive ovarian cancers. They found no association between endometriosis and risk of mucinous or high-grade serous invasive ovarian cancer, however. "Clinicians should be aware of the increased risk of specific subtypes of ovarian cancer in women with endometriosis," the authors write. "Future efforts should focus on understanding the mechanisms that might lead to malignant transformation of endometriosis so as to help identify subsets of women at increased risk of ovarian cancer."

Also in Lancet Oncology this week, researchers in Australia report a meta-analysis of studies on anal HPV infection in men who have sex with men, and the associated neoplastic lesions. The team analyzed data from 53 studies, and found that "anal HPV and anal cancer precursors were very common" in men who have sex with men. "However," the researchers add, "on the basis of restricted data, rates of progression to cancer seem to be substantially lower than they are for cervical pre-cancerous lesions. Large, good-quality prospective studies are needed to inform the development of anal cancer screening guidelines for MSM."

Finally in Lancet Oncology this week, researchers in Japan report results of a phase III trial on the efficacy of neoadjuvant anastrozole versus tamoxifen in patients receiving goserelin for premenopausal breast cancer. The team recruited premenopausal women with ER-positive, HER2-negative, operable breast cancer, and randomly assigned them to receive either goserelin plus anastrozole and tamoxifen placebo, or goserelin plus tamoxifen and anastrozole placebo, before surgery. They found that more patients in the anastrozole group had a complete or partial response, compared to the tamoxifen group. "Given its favorable risk-benefit profile, the combination of anastrozole plus goserelin could represent an alternative neoadjuvant treatment option for premenopausal women with early-stage breast cancer," the authors conclude.

The Scan

Support for Moderna Booster

An FDA advisory committee supports authorizing a booster for Moderna's SARS-CoV-2 vaccine, CNN reports.

Testing at UK Lab Suspended

SARS-CoV-2 testing at a UK lab has been suspended following a number of false negative results.

J&J CSO to Step Down

The Wall Street Journal reports that Paul Stoffels will be stepping down as chief scientific officer at Johnson & Johnson by the end of the year.

Science Papers Present Proteo-Genomic Map of Human Health, Brain Tumor Target, Tool to Infer CNVs

In Science this week: gene-protein-disease map, epigenomic and transcriptomic approach highlights potential therapeutic target for gliomas, and more