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This Week in the Journal of the National Cancer Institute: Dec 15, 2011


In the Journal of the National Cancer Institute this week, researchers in California and Hawaii examined whether legume, soy, tofu, and isoflavone intake affects endometrial cancer risk in postmenopausal women. Researchers have speculated that the phytochemicals found in these foods reduces the risk of endometrial cancer. For this study, the team analyzed data from 46,027 postmenopausal women who have not undergone a hysterectomy and found that a reduced risk of endometrial cancer was associated with total isoflavone intake, daidzein intake, and genistein intake. However, there was no statistically significant association between endometrial cancer risk and an increased intake of legumes, soy, tofu, or glycitein. "This study suggests that greater consumption of isoflavone-containing foods is associated with a reduced risk of endometrial cancer in this population of non-hysterectomized postmenopausal women," the authors write.

Also in the Journal of the National Cancer Institute this week, researchers in the US and Europe report a study on fine needle aspiration cytology for the detection of metastatic melanoma. Fine needle aspiration cytology is often used to evaluate palpable nodes in patients with melanoma. For this study, the researchers performed fine needle aspiration cytology guided either by palpation or ultrasound in 1,279 patients with suspicious lesions or suspect lymph nodes and found that both methods had similar sensitivity, specificity, and positive and negative predictive values. "FNAC of normal-sized nodes and/or lymph nodes with abnormal ultrasound findings can be used to identify early metastatic disease," the authors write.

The Scan

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Mapping Single-Cell Genomic, Transcriptomic Landscapes of Colorectal Cancer

In Genome Medicine, researchers present a map of single-cell genomic and transcriptomic landscapes of primary and metastatic colorectal cancer.

Expanded Genetic Testing Uncovers Hereditary Cancer Risk in Significant Subset of Cancer Patients

In Genome Medicine, researchers found pathogenic or likely pathogenic hereditary cancer risk variants in close to 17 percent of the 17,523 patients profiled with expanded germline genetic testing.