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This Week in the Journal of the National Cancer Institute: Sep 16, 2011


In the Journal of the National Cancer Institute this week, researchers in Europe present findings from a study of once-only sigmoidoscopy as a strategy for colorectal cancer screening. The team assigned 9,911 individuals between the ages of 55 and 64 to receive flexible sigmoidoscopy screening — 251 subjects in the intervention group were diagnosed with colorectal cancer during the follow-up period, compared with 306 cancer cases in the control group, which received no screening. Of those, 65 subjects in the intervention group died from colorectal cancer as did 83 in the control group. "Overall incidence rates in the intervention and control groups were 144.11 and 176.43, respectively, per 100,000 person-years. ... Mortality rates in the intervention and control groups were 34.66 and 44.45, respectively, per 100,000 person-years," the authors write. "A single flexible sigmoidoscopy screening between ages 55 and 64 years was associated with a substantial reduction of colorectal cancer incidence and mortality."

Also in the Journal of the National Cancer Institute this week, researchers in France and Belgium explore the role of the focal adhesion protein kindlin-1 in breast cancer growth and metastasis to the lung. The team analyzed the expression of kindlin-1 in several human cancers, and found its expression to be consistently higher in tumors than in normal tissues in various cancer types that metastasized to the lung. "Overexpression of kindlin-1 induced changes indicating epithelial–mesenchymal transition and transforming growth factor beta signaling, constitutive activation of cell motility, and invasion," the authors write. "These results suggest a role for kindlin-1 in breast cancer lung metastasis and lung tumorigenesis and ... offer new avenues for therapeutic intervention against cancer progression."

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.