This Week in JAMA

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Shigeo Masuda from Tochigi Medical University in Japan comments on a recent JAMA paper from Andrew Gentles and his colleagues. Previously, the Gentles team reported that a high expression level of a gene signature from self-renewing leukemic stem cells was associated with an adverse outcome in patients with acute myeloid leukemia.

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Rare gene mutations are guiding the search for drugs to manage chronic pain without opioids, according to CNBC.

The new Francis Crick Institute building can get too noisy for some researchers to concentrate, according to the Guardian.

CBS News reports that there are still many vacancies at the White House Office of Science and Technology Policy, but that it's uncertain whether they will be filled.

In Nucleic Acids Research this week: pipeline to analyze and visualize bacterial genomes, database of global set of human genomes, and more.