Skip to main content
Premium Trial:

Request an Annual Quote

This Week in JAMA: Jun 29, 2011


Online first in JAMA this week, Northwestern University Feinberg School of Medicine's June Robinson and Beth Israel Deaconess Medical Center's Michael Bigby present a commentary on the use of sunscreen to prevent melanoma. Evidence from several trials shows that regular use of sunscreen can prevent cutaneous squamous cell carcinoma. One such study, conducted in Australia, included 1.621 adults randomized to regular sunscreen use or discretionary use, including no use at all, the Robinson and Bigby write. In the 10 years after cessation of the trial, 11 new primary melanomas were identified among the 812 people in the sunscreen group compared with 22 melanomas in the discretionary use group. "Since exposure to UV radiation is the only known modifiable cause of melanoma, this study is a potential 'game changer' for the primary prevention of melanoma," Robinson and Bigby say. "Patients at high risk for skin cancer because of phenotypic characteristics (fair skin, freckling, and tendency to sunburn) who live in or visit sunny climates or who have a family history of melanoma should routinely and thoroughly apply sunscreen before going outside." They add that sun protection counseling is relevant for people at risk for developing melanomas.

The Scan

Expanded Genetic Testing Uncovers Hereditary Cancer Risk in Significant Subset of Cancer Patients

In Genome Medicine, researchers found pathogenic or likely pathogenic hereditary cancer risk variants in close to 17 percent of the 17,523 patients profiled with expanded germline genetic testing.

Mitochondrial Replacement Therapy Embryos Appear Largely Normal in Single-Cell 'Omics Analyses

Embryos produced with spindle transfer-based mitochondrial replacement had delayed demethylation, but typical aneuploidy and transcriptome features in a PLOS Biology study.

Cancer Patients Report Quality of Life Benefits for Immune Checkpoint Inhibitors

Immune checkpoint inhibitor immunotherapy was linked in JAMA Network Open to enhanced quality of life compared to other treatment types in cancer patients.

Researchers Compare WGS, Exome Sequencing-Based Mendelian Disease Diagnosis

Investigators find a diagnostic edge for whole-genome sequencing, while highlighting the cost advantages and improving diagnostic rate of exome sequencing in EJHG.