This Week in Clinical Cancer Research | GenomeWeb

In Clinical Cancer Research this week, researchers in Japan and the US report on the role of epigenetic silencing of microRNA-34b/c in the pathogenesis of malignant pleural mesothelioma. The team examined aberrant methylation and expression of miR-34s in malignant pleural mesothelioma cell lines and tumors. They found aberrant methylation in two of six cell lines and 13 of 47 tumors in miR-34a, and found aberrant methylation in all six cell lines and 40 out of 47 tumors in miR-34b/c.

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