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This Week in Cancer Discovery: Mar 23, 2012


In Cancer Discovery this week, researchers in the UK and the Netherlands report that nanoparticle albumin-bound-paclitaxel potentiates gemcitabine activity in a mouse model of pancreatic cancer. Using their model, the researchers show that treatment of pancreatic cancer with a combination of nab-paclitaxel and gemcitabine "uniquely demonstrates evidence of tumor regression." Paclitaxel reduced the levels of the primary gemcitabine metabolizing enzyme, cytidine deaminase, in cultured cells, resulting in an increased stabilization of gemcitabine in those cells, the team found. "Our findings support the concept that suboptimal intratumoral concentrations of gemcitabine represent a crucial mechanism of therapeutic resistance in [pancreatic ductal adenocarcinomas] and highlight the advantages of genetically engineered mouse models in preclinical therapeutic trials," they add.

Also in Cancer Discovery this week, researchers in the US and Europe describe their study of MYC activation in prostate cancer. Over-expression of ubiquitin-specific protease 2a down-regulates a set of microRNAs that collectively increase MYC levels. "By establishing MYC as a target of miR-34b/c, we demonstrate that this cluster functions as a tumor suppressor in prostate cancer cells. We identify a distinct mRNA signature that is enriched for MYC-regulated transcripts and transcription factor binding sites in USP2a overexpressing prostate cancer cells," the authors write. "We demonstrate that these genes are associated with an invasive phenotype in human prostate cancer and that the proliferative and invasive properties of USP2a overexpressing cells are MYC-dependent."

Finally in Cancer Discovery this week, researchers in California say tumor invasion and metastasis in pancreatic neuroendocrine tumors can be suppressed by concurrent inhibition of c-Met and VEGF. The team treated pancreatic neuroendocrine tumors in mice with a neutralizing anti-VEGF antibody, and found that it reduced the tumor burden, but increased tumor hypoxia, hypoxia-inducible factor-1α, and c-Met activation, which in turn increased invasion and metastasis. However, the team also found that adding a c-Met inhibitor concurrent to the VEGF inhibitor reduced invasion and metastasis. "These findings document that invasion and metastasis are promoted by selective inhibition of VEGF signaling and can be reduced by the concurrent inhibition of c-Met," they write.

The Scan

And Back

The New York Times reports that missing SARS-CoV-2 genome sequences are back in a different database.

Lacks Family Hires Attorney

A lawyer for the family of Henrietta Lacks plans to seek compensation from pharmaceutical companies that have used her cancer cells in product development, the Baltimore Sun reports.

For the Unknown

The Associated Press reports that family members are calling on the US military to use new DNA analysis techniques to identify unknown sailors and Marines who were on the USS Arizona.

PLOS Papers on Congenital Heart Disease, COVID-19 Infection Host MicroRNAs, Multiple Malformation Mutations

In PLOS this week: new genes linked to congenital heart disease, microRNAs with altered expression in COVID-19, and more.