This Week in Cancer Discovery


Researchers led by the Dana-Farber Cancer Institute's William Hahn report in Cancer Discovery that the gene CRKL is amplified and over-expressed in non-small cell lung cancers with 22q11.21 amplifications. CRKL. Further, the "over expression of CRKL induces cell transformation and resistance to epidermal growth factor receptor inhibitor treatment and [suggests] that therapeutic interventions targeting CRKL may confer a clinical benefit in a defined subset of NSCLCs," the authors write.

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Researchers hope to tease out the signature effects that different carcinogens leave on the genome to determine their contributions to disease, Mosaic reports.

The Wall Street Journal looks into the cost of new gene therapies.

An Imperial College London-led team reports that it was able to use a gene drive to control a population of lab mosquitos.

In PNAS this week: genomic effects of silver fox domestication, limited effect of mitochondrial mutations on aging in fruit flies, and more.