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This Week in Cancer Discovery: Dec 30, 2011


Researchers led by the Dana-Farber Cancer Institute's William Hahn report in Cancer Discovery that the gene CRKL is amplified and over-expressed in non-small cell lung cancers with 22q11.21 amplifications. CRKL. Further, the "over expression of CRKL induces cell transformation and resistance to epidermal growth factor receptor inhibitor treatment and [suggests] that therapeutic interventions targeting CRKL may confer a clinical benefit in a defined subset of NSCLCs," the authors write.

Johns Hopkins University researchers found that combining epigenetic therapy with chemotherapy led to "durable responses in patients with solid tumors." However, the authors add that "objective responses to this therapy in this heavily pretreated population occurred in only 4 [percent] of the patients, but the antitumor responses that were observed were impressive."

The Scan

Not as High as Hoped

The Associated Press says initial results from a trial of CureVac's SARS-CoV-2 vaccine suggests low effectiveness in preventing COVID-19.

Finding Freshwater DNA

A new research project plans to use eDNA sampling to analyze freshwater rivers across the world, the Guardian reports.

Rise in Payments

Kaiser Health News investigates the rise of payments made by medical device companies to surgeons that could be in violation of anti-kickback laws.

Nature Papers Present Ginkgo Biloba Genome Assembly, Collection of Polygenic Indexes, More

In Nature this week: a nearly complete Ginkgo biloba genome assembly, polygenic indexes for dozens of phenotypes, and more.