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This Week in Cancer Discovery: Dec 30, 2011

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Researchers led by the Dana-Farber Cancer Institute's William Hahn report in Cancer Discovery that the gene CRKL is amplified and over-expressed in non-small cell lung cancers with 22q11.21 amplifications. CRKL. Further, the "over expression of CRKL induces cell transformation and resistance to epidermal growth factor receptor inhibitor treatment and [suggests] that therapeutic interventions targeting CRKL may confer a clinical benefit in a defined subset of NSCLCs," the authors write.

Johns Hopkins University researchers found that combining epigenetic therapy with chemotherapy led to "durable responses in patients with solid tumors." However, the authors add that "objective responses to this therapy in this heavily pretreated population occurred in only 4 [percent] of the patients, but the antitumor responses that were observed were impressive."

The Scan

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.

Study Highlights Pitfall of Large Gene Panels in Clinical Genomic Analysis

An analysis in Genetics in Medicine finds that as gene panels get larger, there is an increased chance of uncovering benign candidate variants.

Single-Cell Atlas of Drosophila Embryogenesis

A new paper in Science presents a single-cell atlas of fruit fly embryonic development over time.

Phage Cocktail Holds Promise for IBD

Researchers uncovered a combination phage therapy that targets Klebsiella pneumonia strains among individuals experiencing inflammatory bowel disease flare ups, as they report in Cell.