This Week in Cancer Cell | GenomeWeb

This Week in Cancer Cell

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In Cancer Cell this week, a team led by researchers at MD Anderson Cancer Center report that p53-mediated senescence in breast cancer cells impairs the apoptotic response to chemotherapy. The team shows that mammary tumors with mutant p53 exhibit a "superior clinical response" compared to tumors with wild-type p53 — p53 mutant tumors treated with doxorubicin continued to proliferate, leading to abnormal mitosis, whereas wild-type p53 tumors arrested when treated with doxorubicin.

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Harold Varmus, a former NIH director, says that proposed reductions to the agency's budget are worrisome.

The Genome 10K project is to sequence about 10,000 vertebrate genomes, including ones of endangered species, Digital Trends reports.

The new Coalition to Save NIH Funding aims to educate lawmakers and the public on the significance of biomedical research.

In PLOS this week: analysis of viral sequences from human blood samples, gut microbiomes of heart failure patients, and more.