This Week in Cancer Cell


In Cancer Cell this week, researchers in France, Spain, and the Netherlands present a mouse model of small-cell lung cancer that they say shows a functional role for tumor cell heterogeneity. SCLC tumors are often composed of neuroendocrine and mesenchymal cells, and mesenchymal cells can endow neuroendocrine cells with metastatic capacity, the authors write. Oncoprotein RasV12 can make neuroendocrine cells transition to a mesenchymal phenotype, facilitating metastasis.

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The apple has traveled westward and eastward along the Silk Road, according to a new genetic analysis.

In Nature this week: GWAS data used to reposition drugs for psychiatric use, and more.

Genetic disease risk information doesn't always spur people to make healthy lifestyle changes, according to the Associated Press.

A University of California, San Diego-led team has used liquid biopsies to uncover possible treatments for patients with cancers of unknown primary.