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This Week in the British Journal of Cancer: May 9, 2011


In the British Journal of Cancer this week, researchers in California and China say that downregulation of SOX2 in cancer stem cells suppresses the growth and metastasis of lung cancer. The researchers show that D121-SP cancer cells contain cancer stem cell characteristics as demonstrated by an upregulation of transcription factors SOX2 and Oct 4. More importantly, the migration of D121-SP was decreased and apoptosis was upregulated after a knockdown of SOX2 in the cells, the authors write. "Downregulation of SOX2 in D121 cells markedly suppressed their metastatic potential in syngeneic mice," they add.

Also in the British Journal of Cancer this week, a team from Yale University School of Medicine presents findings from a study of effective treatment of chemotherapy-resistant breast cancer in vitro and in vivo using a factor VII-targeted photodynamic therapy. The in vitro efficacy of the targeted photodynamic therapy was 12-fold stronger than that of non-targeted photodynamic therapy in MCF-7 and MDR breast cancer cells, the authors write. In addition, the targeted therapy was effective and safe for the treatment of chemoresistant breast tumors in nude mouse models. "We conclude that fVII-tPDT is effective and safe for the treatment of chemoresistant breast cancer, presumably by simultaneously targeting both the tumour neovasculature and chemoresistant cancer cells," the researchers add. "Thus, this dual-targeting fVII-tPDT could also have therapeutic potential for the treatment of other chemoresistant cancers."

And finally in the British Journal of Cancer this week, researchers in Canada determine the cost effectiveness of outpatient treatment for febrile neutropaenia in adult cancer patients. The researchers compared four treatment strategies for low-risk febrile neutropaenia. They found that the option of outpatient management with oral antibiotics saved money, but was less effective than outpatient management with IV antibiotics. "For adult cancer patients with an episode of low-risk FN, treatment in hospital is more expensive and less effective than outpatient strategies," the authors write.

The Scan

Researchers Compare WGS, Exome Sequencing-Based Mendelian Disease Diagnosis

Investigators find a diagnostic edge for whole-genome sequencing, while highlighting the cost advantages and improving diagnostic rate of exome sequencing in EJHG.

Researchers Retrace Key Mutations in Reassorted H1N1 Swine Flu Virus With Avian-Like Features

Mutations in the acidic polymerase-coding gene boost the pathogenicity and transmissibility of Eurasian avian-like H1N1 swine influenza viruses, a PNAS paper finds.

Genome Sequences Reveal Evolutionary History of South America's Canids

An analysis in PNAS of South American canid species' genomes offers a look at their evolutionary history, as well as their relationships and adaptations.

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.