This Week in the British Journal of Cancer | GenomeWeb

In the British Journal of Cancer this week, researchers in the Netherlands analyze the risk of renal cancer and pneumothorax in 35 families with Birt-Hogg-Dubé syndrome, an autosomal dominant condition caused by mutations in the FLCN gene. The team confirmed a high yield of FLCN mutations in clinically defined BHD families, and found that they carried a substantially increased lifetime risk for renal cancer of 16 percent. The patients also had a 29 percent increased risk for pneumothorax.

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