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This Week in the British Journal of Cancer: Aug 16, 2011


In the British Journal of Cancer this week, UK researchers present findings from a study on the ethnic differences in prostate cancer. The team reviewed data from the US, which suggests that African-American men have a 60 percent higher risk for developing prostate cancer than their white counterparts. African-American men also have poorer prognoses for the disease, the researchers added. "This has implications for policy development, awareness raising among black men in each country and clinical practice," the team adds.

Also in the British Journal of Cancer this week, researchers in the US, Israel, and Spain present a study on how genes in the adiponectin pathway affect a person's risk for colorectal cancer. "Genes of the adiponectin pathway are interesting candidates for colorectal cancer risk based on the potential association between colorectal cancer and obesity," the authors write. "However, variants of the adiponectin gene have been demonstrated to be inconsistently associated with risk of colorectal cancer." The team examined several SNPs in the adiponectin pathway, and performed genotyping for a previously reported risk variant in 1,062 colorectal cancer patients and 1,062 controls. In the end, however, the team found no evidence of an association between adiponectin and risk of colorectal cancer.

Finally in the British Journal of Cancer this week, US researchers present findings on the prognostic impact of lymphadenectomy in early-stage malignant germ cell tumors of the ovary. The team analyzed data from 1,083 patients with ovarian germ cell tumors who had undergone surgery. Of those, 590 did not have lymphadenectomies, while 493 did. Patients that did not undergo lymphadenectomies had a 96.9 percent 5-year survival rate while those that did undergo the procedure had a 97.7 percent survival rate. In addition, patients that were upgraded to stage IIIc disease due to nodal metastasis had a 93.4 percent survival rate. "On multivariate analysis, lymphadenectomy was not an independent predictor of survival when controlling for age, histology and race," the researchers add.

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