This Week in BMC Cancer


In BMC Cancer this week, researchers in France report that ligand-free estrogen receptor activity works with IGF1R to induce proliferation in MCF-7 breast cancer cells. The team evaluated the effects of ER ligand agonist estradiol and the IGF1R ligand insulin in MCF-7 cells, and found that the activation of ER by estradiol doesn't induce cell cycle progression while PI3K/Akt signaling is blocked by a chemical inhibitor or by siRNA targeting Akt1 and Akt2.

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The London School of Economics' Daniele Fanelli argues at the Proceedings of the National Academy of Sciences that the reproducibility crisis in science isn't as dire as some say.

A team of researchers in Portugal has examined the genomic basis for racing pigeons' athleticism and navigational skills, finding it's likely polygenic.

Wired reports that diagnostic firms continue to seek, post-Theranos, the ability to diagnose diseases from small amounts of blood.

In Science this week: analysis of DNA from ancient North Africans, and more.