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This Week in BMC Cancer : Jul 2, 2012

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A team led by scientists at the Korea Research Institute of Bioscience and Biotechnology in Daejeon, South Korea, this week presents in BMC Cancer a 3D structure for GIG47 — a candidate oncogene implicated in multiple human cancers — which they determined using multidimensional heteronuclear NMR methods. The authors say the structure they report could facilitate future development of anticancer agents.

Also in BMC Cancer this week, researchers at Germany's Martin Luther University Halle-Wittenberg report having found "a significant association between the expression of Piwi-like 2 and 4 mRNAs and the tumor-specific survival of soft tissue sarcoma patients." Measuring expression of those Piwi-like mRNAs in 125 soft tissue sarcoma samples using qPCR, later applying statistical tests to correlate expression readouts with patient survival, the researchers also identified a connection between sex and the impact of Piwi-like mRNA expression on soft tissue sarcoma patients' prognosis, they write.

The Scan

Follow-Up Data Requests to Biobank Participants Ineffective, Study Finds

An effort to recontact biobank enrollees for additional information reports low participation in a new BMJ Open study.

Study Finds Widespread Transmission of Resistant Bacteria in Vietnam Hospitals

A sequencing study in The Lancet Microbe finds widespread transmission of drug-resistant Escherichia coli, Klebsiella pneumoniae, and Acinetobacter baumannii in two Vietnam ICUs.

Novel Brain Cell Organoids Show Promise for Autism Research

University of Utah researchers report in Nature Communications on their development of brain cell organoids to study SHANK3-related autism.

Study Finds Few FDA Post-Market Regulatory Actions Backed by Research, Public Assessments

A Yale University-led team examines in The BMJ safety signals from the US FDA Adverse Event Reporting System and whether they led to regulatory action.