In BMC Cancer this week, researchers in China say that over-expression of microRNAs in the miRNA-183 family is a risk factor for lung cancer. The team examined the expression of miRNAs 96, 182, and 183 in 70 paired samples from lung cancer patients as well as 44 serum samples from healthy individuals, and found that expression levels of these miRNAs in lung cancer tumor tissue and serum were higher than in their normal counterparts. "Our results suggest that the expressions of miR-96, miR-182, and miR-183 in tumor and sera may be considered potential novel biomarkers for the diagnosis and prognosis of lung cancer," the authors write.
Also in BMC Cancer this week, a separate team of Chinese researchers write that SNPs in the ICOS gene are associated with sporadic breast cancer. The team genotyped five SNPs in the ICOS gene among 609 breast cancer patients and 665 healthy controls. It found that certain variants of rs10932029 were linked to an increased risk of breast cancer, and a variant of rs11889031 was associated with progesterone receptor status and lymph node metastasis.
And finally in BMC Cancer this week, researchers conduct a meta-analysis of the association between prostate cancer risk and the hOGG1 Ser326Cys polymorphism. The team analyzed data from 2,584 total prostate cancer cases and 3,234 controls, and found that Ser326Cys was not associated with prostate cancer risk in the overall population. There was, however, an association between the cancer and polymorphism in certain subgroups in the population, though not in Caucasian patients.