Skip to main content
Premium Trial:

Request an Annual Quote

This Week in BMC Cancer: Aug 2, 2011


In BMC Cancer this week, researchers in the US and Puerto Rico present results from a case-control study of the link between smoking and drinking and oral, potentially malignant disorders in Puerto Rico. The team analyzed the smoking and drinking habits of 86 patients diagnosed with an oral, potentially malignant disorder, and 155 with a benign oral tissue condition, and found that current smoking was a substantial risk factor for the malignant disorders. Former smokers had a far smaller risk of developing a malignancy, compared to current smokers, the authors added. There was very little evidence to suggest that alcohol consumption influenced risk.

Also in BMC Cancer this week, researchers in the UK and China say that cancer stem cell CD133 has the potential to be used as an indicator for differentiation and prognosis in human cholangiocarcinoma. The researchers analyzed five normal liver samples and 54 cholangiocarcinoma samples, and found that CD133 was expressed in all five normal samples and 40 out of the 54 cancerous samples. "Further statistical analyses indicated that the expression and different subcellular localization of CD133 were significantly correlated with the differentiation status of tumors," the authors write. "Among 23 patients followed up for survival, the median survival was four months for 14 CD133 negative patients but 14 months for nine CD133 positive ones. CD133 negative expression correlated with poor prognosis."

Finally in BMC Cancer this week, South Korean researchers present findings from a multi-center retrospective analysis of 581 patients with primary intestinal non-Hodgkin lymphoma. The team compared clinical features and treatment outcomes according to anatomical site and histological subtype. The team found that B-cell lymphoma was more frequent that T-cell lymphoma, and that T-cell lymphoma had more "unfavorable characteristics" like advanced stage at diagnosis, and a lower survival rate. "The survival of patients with ileocecal region involvement was better than that of patients with involvement at other sites, which might be related to histologic distribution, the proportion of tumor stage, and need for surgical resection," the team adds.

The Scan

Y Chromosome Study Reveals Details on Timing of Human Settlement in Americas

A Y chromosome-based analysis suggests South America may have first been settled more than 18,000 years ago, according to a new PLOS One study.

New Insights Into TP53-Driven Cancer

Researchers examine in Nature how TP53 mutations arise and spark tumor development.

Mapping Single-Cell Genomic, Transcriptomic Landscapes of Colorectal Cancer

In Genome Medicine, researchers present a map of single-cell genomic and transcriptomic landscapes of primary and metastatic colorectal cancer.

Expanded Genetic Testing Uncovers Hereditary Cancer Risk in Significant Subset of Cancer Patients

In Genome Medicine, researchers found pathogenic or likely pathogenic hereditary cancer risk variants in close to 17 percent of the 17,523 patients profiled with expanded germline genetic testing.