In BMC Cancer this week, researchers in South Korea say that T lymphocytes derived from human cord blood provide effective immunotherapy to protect against tumors in humans. The researchers transplanted cord blood mononuclear cells and tumor cells into mice, and found "dramatic tumor remission" following transfer of the cord blood cells. "Mice that receive neonatal cord blood transplants have reconstituted T cells with significant antitumor effects against human cervical and lung tumors, with a high infiltration of CD3+ T cells showing dramatic induction of apoptotic cell death," the authors write. "We also confirmed that T cells showed tumor specific antigen cytotoxicity in vitro."
Also in BMC Cancer this week, researchers in California present findings from a study of the effects of herbal remedies on survival and quality of life in long-term breast cancer survivors. The researchers collected information on herbal remedy use and quality of life from 371 women who had survived more than 10 years after being diagnosed with breast cancer. They found that 59 percent of participants were herbal remedy users, the most common being echinacea, herbal teas, and gingko biloba, and that herbal remedy use was associated with non-statistically significant increases in the risks for all-cause deaths and breast cancer mortality. "Our data provide some evidence that herbal remedy use is associated with poorer survival and a poorer physical component score for health-related quality of life among women who have survived breast cancer for at least 10 years," the authors write.
Finally in BMC Cancer this week, researchers in the UK and the US present findings from a study on the synergistic effects of oncolytic reovirus and docetaxel chemotherapy in the treatment of prostate cancer. The researchers assessed the effects of this combination therapy on PC3 and Du 145 cell lines, and found that it led to increased late apoptotic and necrotic cell populations, reduced tumor growth, and increased survival in a PC3 tumor-bearing mouse model.