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This Week in BMC Cancer: Mar 15, 2011


In BMC Cancer this week, researchers in China present a meta-analysis of cohort studies on the association between coffee consumption and cancer risk. The team searched various databases and found 59 studies that showed individuals who didn't or seldom drank coffee had a higher relative risk of developing cancer than people who drank coffee regularly. "Overall, an increase in consumption of one cup of coffee per day was associated with a 3 percent reduced risk of cancers," the authors write. "In subgroup analyses, we noted that coffee drinking was associated with a reduced risk of bladder, breast, buccal and pharyngeal, colorectal, endometrial, esophageal, hepatocellular, leukemic, pancreatic, and prostate cancers."

Also in BMC Cancer this week, researchers in France present their validation of prognostic models for survival in patients undergoing chemotherapy for advanced or metastatic cancer after first-line treatment. The team previously described a model for prognosis based on a combination of Performance Status — a scale used by clinicians to measure how a patient's disease is affecting their daily habits — and either lactate dehydrogenase level or lymphocyte count. "Prognostic scores using Performance Status plus LDH level or Performance Status plus lymphocyte count were validated for predicting survival in metastatic cancer patients in relapse beyond first-line treatment," the authors write. "A score combining PS, LDH, lymphocyte and platelet count, serum albumin, and IL-6 level was superior in determining patients' prognosis."

Finally in BMC Cancer this week, researchers in Spain propose a study to determine the effects of manual lymphatic drainage therapy in women with breast cancer-related lymphoedema. The researchers propose a randomized controlled clinical trial of 58 women suffering post-mastectomy lymphoedema and a control group of 29 patients receiving standard-of-care therapy. "The results of this study will provide information on the effectiveness of manual lymph drainage and its impact on the quality of life and physical limitations of these patients," the researchers write.

The Scan

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New Insights Into TP53-Driven Cancer

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Mapping Single-Cell Genomic, Transcriptomic Landscapes of Colorectal Cancer

In Genome Medicine, researchers present a map of single-cell genomic and transcriptomic landscapes of primary and metastatic colorectal cancer.

Expanded Genetic Testing Uncovers Hereditary Cancer Risk in Significant Subset of Cancer Patients

In Genome Medicine, researchers found pathogenic or likely pathogenic hereditary cancer risk variants in close to 17 percent of the 17,523 patients profiled with expanded germline genetic testing.