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Vanderbilt Scientists Find Fingerprint for Lung Cancer

NEW YORK, Aug. 8 (GenomeWeb News) - A protein fingerprint of 15 proteins can be used to predict the prognosis of lung cancer patients, the Aug. 9 issue of the Lancet reported.


Scientists at VanderbiltUniversity showed that profiles obtained from small amounts of tissue fed through a mass spectrometer and analysis software could distinguish lung cancer tissue from normal tissue with 100 percent accuracy, and could also predict the risk of the cancer spreading to lymph nodes.


Since it was first introduced by Emanuel Petricoin, Lance Liotta, and others in the Feb. 2002 issue of Lancet, protein fingerprinting as a diagnostic tool has been studied for possible applications to ovarian, breast, prostate and lung cancer.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.