For Oliver Rando, being in Tom Maniatis’ Harvard lab when the PI and his team worked out the role of the proteasome in NF-KB activation made the difference between a career in research and one with possibility for direct clinical impact.

Being a member of the lab during its groundbreaking work on NF-KB — the work that led to today’s use of proteasome inhibitors as the frontline treatment for multiple myeloma, Rando says — was the pivotal element in his deciding to get an MD in addition to the PhD he already had in mind.

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