Skip to main content
Premium Trial:

Request an Annual Quote

UBC-Led Team Sequences Rhodococcus sp. RHA1, Largest Bacterial Genome to Date

NEW YORK, March 21 (GenomeWeb News) - An international team led by researchers at the University of British Columbia has sequenced the genome of Rhodococcus sp. RHA1, a soil bacterium of interest for bioremediation research.


At more than 9.7 million base pairs, Rhodococcus sp. RHA1 is the largest bacterial genome sequenced to date, according to the UBC team, and is the first genome of a Rhodococcus to be completely sequenced.


Analysis of the sequence indicates the presence of more than 9,300 genes, including several that encode proteins that break down toxic substances such as polychlorinated biphenyls, toluene, and phthalates. The genome of Rhodococcus sp. RHA1 also contains a number of genes related to antibiotic production.


The team has also verified the expression of approximately 3,000 transcripts and approximately 250 proteins in subsequent studies using high-throughput proteomics, transcriptomics, and gene disruption.


The sequencing and assembly of the genome was performed at the MichaelSmithGenomeSciencesCenter, while the sequence analysis and subsequent experimental research was performed by the Microbial Envirogenomics Group at UBC. The project marks the first bacterial genome to be entirely sequenced and annotated in Canada.


The sequence and annotation of the Rhodococcus sp. RHA1 genome will be formally presented at the International Conference on Microbial Genomes, April 13-16, in Halifax, Nova Scotia.


More information on the Rhodococcus Genome Project is available here.

The Scan

Study Finds Sorghum Genetic Loci Influencing Composition, Function of Human Gut Microbes

Focusing on microbes found in the human gut microbiome, researchers in Nature Communications identified 10 sorghum loci that appear to influence the microbial taxa or microbial metabolite features.

Treatment Costs May Not Coincide With R&D Investment, Study Suggests

Researchers in JAMA Network Open did not find an association between ultimate treatment costs and investments in a drug when they analyzed available data on 60 approved drugs.

Sleep-Related Variants Show Low Penetrance in Large Population Analysis

A limited number of variants had documented sleep effects in an investigation in PLOS Genetics of 10 genes with reported sleep ties in nearly 192,000 participants in four population studies.

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.