In a new study in Nature Medicine, researchers from the Fred Hutchinson Cancer Research Center and their collaborators report that the effect of chemotherapy on healthy cells surrounding tumors can lead to treatment resistance, says BBC News. The study suggests that chemotherapeutic agents activate fibroblast cells around the tumor that normally heal wounds and produce collagen, and that these cells cause cancer cells to become resistant to further treatment by bulking up the tumor microenvironment, the BBC says. "Chemotherapy causes DNA damage that causes the fibroblasts to produce up to 30 times more of a protein called WNT16B than they should," the BBC adds. "The protein fuels cancer cells to grow and invade surrounding tissue — and to resist chemotherapy."
Aug 07, 2012