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In a new study in Nature Medicine, researchers from the Fred Hutchinson Cancer Research Center and their collaborators report that the effect of chemotherapy on healthy cells surrounding tumors can lead to treatment resistance, says BBC News. The study suggests that chemotherapeutic agents activate fibroblast cells around the tumor that normally heal wounds and produce collagen, and that these cells cause cancer cells to become resistant to further treatment by bulking up the tumor microenvironment, the BBC says. "Chemotherapy causes DNA damage that causes the fibroblasts to produce up to 30 times more of a protein called WNT16B than they should," the BBC adds. "The protein fuels cancer cells to grow and invade surrounding tissue — and to resist chemotherapy."

The Scan

Mosquitos Genetically Modified to Prevent Malaria Spread

A gene drive approach could be used to render mosquitos unable to spread malaria, researchers report in Science Advances.

Gut Microbiomes Allow Bears to Grow to Similar Sizes Despite Differing Diets

Researchers in Scientific Reports find that the makeup of brown bears' gut microbiomes allows them to reach similar sizes even when feasting on different foods.

Finding Safe Harbor in the Human Genome

In Genome Biology, researchers present a new approach to identify genomic safe harbors where transgenes can be expressed without affecting host cell function.

New Data Point to Nuanced Relationship Between Major Depression, Bipolar Disorder

Lund University researchers in JAMA Psychiatry uncover overlapping genetic liabilities for major depression and bipolar disorder.