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In a new study in Nature Medicine, researchers from the Fred Hutchinson Cancer Research Center and their collaborators report that the effect of chemotherapy on healthy cells surrounding tumors can lead to treatment resistance, says BBC News. The study suggests that chemotherapeutic agents activate fibroblast cells around the tumor that normally heal wounds and produce collagen, and that these cells cause cancer cells to become resistant to further treatment by bulking up the tumor microenvironment, the BBC says. "Chemotherapy causes DNA damage that causes the fibroblasts to produce up to 30 times more of a protein called WNT16B than they should," the BBC adds. "The protein fuels cancer cells to grow and invade surrounding tissue — and to resist chemotherapy."

The Scan

Two J&J Doses

Johnson & Johnson says two doses of its SARS-CoV-2 vaccine provides increased protection against symptomatic COVID-19, CNN reports.

Pfizer-BioNTech Vaccine Response in Kids

The Pfizer-BioNTech SARS-CoV-2 vaccine in a lower-dose format appears to generate an immune response among children, according to the Washington Post.

Chicken Changes to Prevent Disease

The Guardian writes that researchers are looking at gene editing chickens to help prevent future pandemics.

PNAS Papers on Siberian Dog Ancestry, Insect Reproduction, Hippocampal Neurogenesis

In PNAS this week: ancestry and admixture among Siberian dogs, hormone role in fruit fly reproduction, and more.