Often called the guardian of the genome or the master tumor suppressor gene, p53 has long been known to keep tumors at bay. Now, recent research shows that three microRNAs help p53 out, especially in preventing lung cancer. Previous studies focused mainly on the coding genes that p53 regulates, but recently, researchers have begun to take an interest in non-coding genes’ roles in tumor development as well, says Guido Bommer, a postdoctoral fellow in Eric Fearon’s lab at the University of Michigan.

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