Investors are constantly asking entrepreneurs when profits will materialize so they can begin accurately calculating their return on investment. In device, tool, and diagnostic companies, these calculations are relatively straightforward. But for therapy companies there is an elephant in the room that is often mentally downsized or ignored.

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Senator Elizabeth Warren (D-Mass.) has released the results of a genetic ancestry analysis, the Boston Globe reports.

Retraction Watch's Ivan Oransky and Adam Marcus report that Harvard Medical School and Brigham and Women's Hospital have recommended that more than 30 papers from a former researcher be retracted.

Thomas Steitz, who won the 2009 chemistry Nobel Prize for his ribosome work, has died, the Washington Post reports.

In PLOS this week: mechanisms for genes implicated in coronary artery disease, rumen microbes and host genetics influence cow methane production, and more.