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Transgenomic, Key Genomics Teaming on Ovarian Cancer Treatment Test

NEW YORK (GenomeWeb News) – Transgenomic said today that it will work with Key Genomics to develop a molecular test to help physicians find out which ovarian cancer patients will respond to a certain drug treatment.
The test will couple Key Genomics’ coexpression extrapolation, or COXEN, predictive algorithm with Transgenomic’s DNA mutation detection analysis technology to predict epithelial carcinoma of the ovary.
Transgenomic said that its mutation and analysis technologies will “complement and enhance” the COXEN algorithm, which uses genomic and pharmacological response data about cancer lines to generate molecular response signatures to specific anti-cancer agents. The companies aim for the test to provide optimal therapy recommendations based on the specific characteristics of a patient’s tumor.
Because ovarian cancers are often diagnosed only after the tumor has spread beyond the ovary, getting “the best therapeutics option as quickly as possible is a key factor in survival,” Transgenomic CEO Craig Tuttle said in a statement. Using the COXEN-derived test that distinguishes which patients will benefit from a certain therapy, Tuttle said, “we believe physicians will be able to quickly direct ovarian cancer patients towards appropriate lines of therapy.”

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