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Tracking Texas

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With more than $1.1 billion in NIH grant funding awarded to researchers in this state, Texas ranks as one of the biomedical heavyweights. As far as genomics goes, scientists here have the genome sequencing center at Baylor in addition to the state’s many universities to contribute to the cause. To compile this chart, GT sorted through NIH’s grants-by-state database to find ones clearly related to the disciplines under the systems biology umbrella, and for the sake of space, selected those with the most funding.

This list, current as of May, is not comprehensive.

 

AWARD, PI, PROJECT


BAYLOR COLLEGE OF MEDICINE

$30,375,487 Richard Gibbs, Large-Scale Sequencing at BCM-HGSC

$2,572,807 Kent Osborne, Translational Research in Breast Cancer

$2,344,662 Kent Osborne, Novel Gene Networks in Breast Development and Cancer

$2,093,809 Robert Schwartz, Genetic Approaches to Early Cardiac Development

$1,491,672 Lawrence Chan, Pathobiology and Gene Transfer in Cardiovascular Disease

$1,284,707 Gretchen Darlington, Gene Expression and Discovery in Liver and Gut Stem Cell

$1,202,261 Jeffrey Noebels, Parallel Sequence Profiling of Ion Channels in Epilepsy

$1,148,666 Adam Kuspa, Functional Genomics of Dictyostelium

$783,741 Hugo Bellen, Transposon Induced Disruption of Most Drosophila Genes

$774,578 James Lupski, Chromosome Rearrangements and Mental Retardation

$645,999 Wah Chiu, Toward a Computation Center for Biomolecular Complexes

$582,756 Bert O’Malley, Sex Hormone Receptor Components and the Cell Genome

$579,009 David Nelson, Sequence and Haplotypes for Analysis of Cancer Genes

$529,409 Ching Lau, Genomic Profile-Based Prognostic Markers for Ependymoma

$500,000 Richard Gibbs, Large-Scale Sequencing at BCM-HGSC

$488,014 Aleksandar Milosavljevic, Clone-Array Pooled Shotgun Indexing

$484,463 Michael Metzker, Ultrafast SBS Method for Large-Scale Human Resequencing


IONWERKS

$900,532 Albert Schultz, New Approach to Proteomics


MD ANDERSON CANCER CENTER

$1,541,017 Randy Legerski, Processing of Complex Lesions in the Mammalian Genome

$1,262,276 Marcelo Aldaz, Gene Expression Signature of Early Breast Cancer

$1,115,022 Mienchie Hung, Growth Factor Receptor Signaling in Breast Cancer

$481,576 Christopher Amos, Positional Gene Identification of Complex Traits


SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH

$2,857,400 John Vandeberg, Diet and Genotype in Primate Atherosclerosis

$642,659 John Blangero, Quantitative Trait Locus Mapping in Human Pedigrees

$534,184 Jean MacCluer, Genetic Analysis of Common Diseases: An Evaluation


TEXAS A&M UNIVERSITY

$539,672 Raymond Carroll, Nutrition, Biostatistics, and Bioinformatics


UNIVERSITY OF HOUSTON

$921,586 Dan Wells, Genetic Map of the Xenopus Tropicalis Genome


UNIVERSITY OF TEXAS, AUSTIN

$490,322 Robert Harris, Gene Expression in the Human Alcoholic Brain


UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER

$1,321,484 Jan Vijg, DNA Repair, Mutations, and Cellular Aging

$1,152,596 Eric Boerwinkle, Modeling DNA Diversity in Reverse Cholesterol Transport

$969,760 Mary MacDougall, Gene Expression Regulation During Odontagenesis

$902,318 Jan Vijg, Models for DNA Repair and Cell Cycle Control Variants

$620,026 Ian Thompson, San Antonio Center of Biomarkers of Risk for Prostate Cancer

$605,835 Michael Escamilla, Population-based Mapping of Schizophrenia Genes


UNIVERSITY OF TEXAS MEDICAL BRANCH, GALVESTON

$1,230,272 David Gorenstein, Biodefense Proteomics Collaboratory

$581,767 Robert Rose, Integrative Biology of the Brain, Inflammation & Asthma


UNIVERSITY OF TEXAS SOUTHWEST MEDICAL CENTER

$9,164,980 Alfred Gilman, Alliance for Cellular Signaling - Phase II

$3,571,363 Steven McKnight, Intracellular Pathways Relevant to Human Cancer

$962,028 Craig Malloy, Southwestern NMR Center for In Vivo Metabolism

$725,400 Stephen Johnston, Genomics and Proteomics of Cell Injury and Inflammation

 

The Scan

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A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.