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Tips for Targeted Cancer Treatment

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Personalized medicine is gaining ground in the clinic, but when it comes to cancer treatment, it has both advantages and disadvantages, says Scientific American guest blogger Karen Ventii. A personalized approach to cancer can result in better treatment for the patient and a reduced cost for care, but it can also increase cancer cells' potential to develop resistance to treatment. To get around this, Ventti says, it may be necessary to use targeted therapies in combination with either other targeted therapies or more conventional ones. "Cancer is a complex genetic disease and as more is learned about the genetic mechanics of cancer growth, the hope is that this knowledge will be leveraged to identify new molecular diagnostics and provide new strategies for tailoring therapies to fit the needs of each cancer patient's unique biology," she adds.

The Scan

For Better Odds

Bloomberg reports that a child has been born following polygenic risk score screening as an embryo.

Booster Decision Expected

The New York Times reports the US Food and Drug Administration is expected to authorize a booster dose of the Pfizer-BioNTech SARS-CoV-2 vaccine this week for individuals over 65 or at high risk.

Snipping HIV Out

The Philadelphia Inquirer reports Temple University researchers are to test a gene-editing approach for treating HIV.

PLOS Papers on Cancer Risk Scores, Typhoid Fever in Colombia, Streptococcus Protection

In PLOS this week: application of cancer polygenic risk scores across ancestries, genetic diversity of typhoid fever-causing Salmonella, and more.