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TIGR Sequences Genome of T. Denticola, a Dental Spirochete

NEW YORK, April 2 (GenomeWeb News) - Scientists from the Institute for Genomic Research announced Monday that they have sequenced the oral spirochete bacterium Treponema denticola.


T. denticola, which causes periodontal disease, was found to contain twice as many genes as T. pallidum, the related spirochete that causes syphilis. This indicated that the two species diverged a long time ago, according to TIGR.


TIGR said additionally that it is now in the process of sequencing the genomes of six other oral-cavity bacteria.


The sequence will be described in the April 13 issue of the Proceedings of the National Academy of Sciences, and was published online this week. The research was conducted in collaboration with scientists at Baylor College of Medicine and the University of Texas Health Science Center at Houston. It was funded by the National Institute of Dental and Craniofacial Research.


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