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TIGR Sequences Genome of Infectious Fungus

NEW YORK, Dec. 21 (GenomeWeb News) - Researchers from the Institute of Genomic Research said today that they have sequenced the genome of the mold Aspergillus fumigatus.


The most common mold causing infection, A. fumigatus triggers allergic reactions, asthma attacks, and deadly infections among people with weakened immune systems.


The A. fumigatus genome is 28 million bases in size, consisting of 8 chromosomes bearing a total of almost 10,000 genes. Researchers found 700 A. fumigatus genes that differed or did not occur in a similar fungus Neosartorya fischeri.


A paper on the researchers' findings will appear in the Dec. 22 issue of the journal Nature.


The paper's first author, TIGR's William Nierman, co-authored two additional Aspergillus genome papers in the same issue of Nature. One describes a study of A. oryzae, a nonpathogenic organism that produces sake, miso, and soy sauce. The other paper reports the genome sequence of A. nidulans and compares it to A. oryzae and A. fumigatus.


The work was carried out collaboratively at several institutions in the US, UK, Spain, Japan, France, Brazil, Austria, Switzerland, and Germany.


The National Institute of Allergy and Infectious Diseases funded a portion of the project.

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