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TIGR, Sanger Say Diarrhea Amoeba Nastier Than Thought

NEW YORK, Feb. 23 (GenomeWeb News) - The Institute for Genomic Research and the Wellcome Trust Sanger Institute have learned that a parasitic amoeba that causes severe diarrheal disease in developing countries has a combination of sensory genes and bacteria-like genes that make its biology unusual.


The two institutes will publish the results of their findings on the genome sequence of Entamoeba histolytica in the Feb. 24 issue of Nature in what they claim is the first genome-wide study of an amoeba and the first genome sequence to be published from this amoeba's class of amitochondrial human pathogens.


The duo of institutes expect the genome sequence to help in the development of new vaccines as well as diagnostic tests that can distinguish the amoeba's most deadly strains. The two say E. histolytica, which causes a disease called amebiasis, infects an estimated 50 million people and causes as many as 100,000 deaths a year -- second only to malaria as a cause of morbidity and mortality from a protist.


The research that led to the discovery was funded by grants from Wellcome Trust and the National Institutes of Health.

The Scan

Shape of Them All

According to BBC News, researchers have developed a protein structure database that includes much of the human proteome.

For Flu and More

The Wall Street Journal reports that several vaccine developers are working on mRNA-based vaccines for influenza.

To Boost Women

China's Ministry of Science and Technology aims to boost the number of female researchers through a new policy, reports the South China Morning Post.

Science Papers Describe Approach to Predict Chemotherapeutic Response, Role of Transcriptional Noise

In Science this week: neural network to predict chemotherapeutic response in cancer patients, and more.