Skip to main content
Premium Trial:

Request an Annual Quote

TIGR Completes Sequence of P. Gingivalis

NEW YORK, June 12 – The Institute for Genomic Research has sequenced the genome of Porphyromonas gingivalis , a bacterium thought to be a leading contributor to adult gum disease, the National Institutes of Health said Tuesday.

It is the first oral disease-causing microbe to be completely sequenced. The sequencing project was supported by the NIH’s National Institute of Dental and Craniofacial Research.

" P. gingivalis is one of the most intensely studied dental pathogens," Dennis Mangan, chief of NIDCR's infectious diseases and immunity branch, said in a statement. "There is a large cadre of researchers out there ready to use the sequence data to identify the genetic mechanisms for the organism's virulence and to develop better approaches for preventing or eradicating periodontitis." 

The sequence of P. gingivalis,  a gram-negative anaerobe, contains 2.2 million base pairs, according to the scientists and dental researchers are hoping to able to use the sequence information to identify potential targets for periodontal vaccines and drug therapies.

Currently the primary treatments for periodontitis are deep cleaning and surgery. 

The P. gingivalis  sequence will be posted on the Internet at http://www.tigr.org/tigr-scripts/CMR2/CMRHomePage.spl .

TIGR recently announced that along with the US Department of Agriculture it had sequenced the pathogen  Listeria monocytogenes  serotype 4b strain, which is the type responsible for most food-borne listeriosis outbreaks.

TIGR also received a grant from the National Institute of Allergy and Infectious Diseases to complete the sequencing of Cryptococcus neoformans , an organism that causes cryptococcosis, a potentially deadly fungal disease. 

The Scan

Study Tracks Off-Target Gene Edits Linked to Epigenetic Features

Using machine learning, researchers characterize in BMC Genomics the potential off-target effects of 19 computed or experimentally determined epigenetic features during CRISPR-Cas9 editing.

Coronary Artery Disease Risk Loci, Candidate Genes Identified in GWAS Meta-Analysis

A GWAS in Nature Genetics of nearly 1.4 million coronary artery disease cases and controls focused in on more than 200 candidate causal genes, including the cell motility-related myosin gene MYO9B.

Multiple Sclerosis Contributors Found in Proteome-Wide Association Study

With a combination of genome-wide association and brain proteome data, researchers in the Annals of Clinical and Translational Neurology tracked down dozens of potential multiple sclerosis risk proteins.

Quality Improvement Study Compares Molecular Tumor Boards, Central Consensus Recommendations

With 50 simulated cancer cases, researchers in JAMA Network Open compared molecular tumor board recommendations with central consensus plans at a dozen centers in Japan.