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Thanks to Today's PIs: Dec 1, 2011

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Anne-Lise Børresen-Dale, Oslo University
Charles Lee, Harvard Medical School
Claire Fraser-Liggett, University of Maryland
David Baker, University of Washington
David Clemmer, Indiana University
David Muddiman, North Carolina State University
David Schwartz, University of Wisconsin, Madison
Drew Endy, Stanford University
Eddy Rubin, Joint Genome Institute
Francis Collins, NIH
Gregory Tsongalis, Dartmouth Medical School
Jenny Graves, Australian National University
Jim Collins, Boston University
Joachim Messing, Rutgers University
Joe DeRisi, University of California, San Francisco
Mark Boguski, Harvard Medical School
Mark Gerstein, Yale University
Michael Brudno, University of Toronto
Rick Myers, HudsonAlpha Institute for Biotechnology
Steve Jones, BC Cancer Agency
Tom Tullius, Boston University
Vijay Pande, Stanford University
William Hahn, Dana-Farber Cancer Institute

The Scan

Study Tracks Off-Target Gene Edits Linked to Epigenetic Features

Using machine learning, researchers characterize in BMC Genomics the potential off-target effects of 19 computed or experimentally determined epigenetic features during CRISPR-Cas9 editing.

Coronary Artery Disease Risk Loci, Candidate Genes Identified in GWAS Meta-Analysis

A GWAS in Nature Genetics of nearly 1.4 million coronary artery disease cases and controls focused in on more than 200 candidate causal genes, including the cell motility-related myosin gene MYO9B.

Multiple Sclerosis Contributors Found in Proteome-Wide Association Study

With a combination of genome-wide association and brain proteome data, researchers in the Annals of Clinical and Translational Neurology tracked down dozens of potential multiple sclerosis risk proteins.

Quality Improvement Study Compares Molecular Tumor Boards, Central Consensus Recommendations

With 50 simulated cancer cases, researchers in JAMA Network Open compared molecular tumor board recommendations with central consensus plans at a dozen centers in Japan.