Skip to main content
Premium Trial:

Request an Annual Quote

TGen, IGC Receive $1.35M to Create Molecular Profiling Institute

This article has been updated from a previous version.


NEW YORK, Dec. 10 (GenomeWeb News) - Two nonprofit labs, the Translational Genomics Research Institute and the International Genomics Consortium, have received $1.35 million in seed capital to build a for-profit joint reference laboratory, according to the new laboratory's CEO.


The lab, called the Molecular Profiling Institute, will become the sole United Statesprovider of a prognostic breast-cancer gene-expression microarray made by the Dutch firm Agendia, said MPI CEO Bob Penny and Agendia CEO Bernhard Sixt.


Seed capital for the laboratory was contributed by Scottsdale Healthcare, the Flinn Foundation, AmeriPath, and venture capital firm EA Management, said MPI CEO Bob Penny, who was chief medical officer at IGC. The "A" round of seed funding collection ended in late October, Penny said.


The array, called MammaPrint, will assess breast cancer recurrence risk, collecting expression data on 231 genes, 70 of which are used in prognosis projection, said Sixt. The assay is intended for use in patients younger than 55, who have tumors smaller than 5 centimeters, and are lymph-node negative. It will be available in January.


Penny estimated the number of lymph-node negative breast cancer patients as 70,000 per year in the United States.


Through a partnership with the diagnostic reference lab AmeriPath, the MPI will provide the company's pathologist network and its approximately 3.5 million patients with access to molecular profiling services, including the MammaPrint test. In return, AmeriPath will help the MPI with co-marketing and sales, said TGen.


The MPI will use Human Genome Project data to analyze patient cancers, according to a statement.


The VirginiaG.PiperCancerCenterin Scottsdale, Ariz.also collaborates in the MPI, the statement added.

The Scan

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.

SpliceVault Portal Provides Look at RNA Splicing Changes Linked to Genetic Variants

The portal, described in Nature Genetics, houses variant-related messenger RNA splicing insights drawn from RNA sequencing data in nearly 335,700 samples — a set known as the 300K-RNA resource.

Automated Sequencing Pipeline Appears to Allow Rapid SARS-CoV-2 Lineage Detection in Nevada Study

Researchers in the Journal of Molecular Diagnostics describe and assess a Clear Labs Dx automated workflow, sequencing, and bioinformatic analysis method for quickly identifying SARS-CoV-2 lineages.

UK Team Presents Genetic, Epigenetic Sequencing Method

Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.