NEW YORK (GenomeWeb News) – Epigenetic programs tend to become increasingly out of whack in B-cells as lymphoma develops, progresses, and becomes more aggressive, a new study suggests.

As they reported online last night in PLoS Genetics, researchers from the University of Colorado, Weill Cornell Medical College, the Dana-Farber Cancer Institute, and elsewhere used custom arrays and methylation assays to compare the DNA methylation profiles in normal B-cell samples and samples from the two most common subtypes of non-Hodgkin lymphoma.

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