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TCGA Taps Rubicon for Cancer Sample Amplification

NEW YORK (GenomeWeb News) – Rubicon Genomics will amplify and standardize DNA samples from cancer patients for the Cancer Genome Atlas, the Ann Arbor, Mich.-based company said today.
 
Under an agreement with SAIC-Frederick, Rubicon will use its GenomePlex whole-genome amplification technology on more than 3,000 blood and tissue samples. The DNA libraries will be deposited in the International Genomics Consortium’s Biospecimen Research Core, where they will be shared among international researchers taking part in the TCGA project.
 
Rubicon’s VP of commercial development, John Langmore, said in a statement that IGC collaborators showed “that pre-amplification of patient DNA can increase the sensitivity, reproducibility and robustness of analysis of patient samples using major analytical instruments."
 
Financial terms of the agreement were not released.

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.