Here at Genome Technology, we’re big fans of the “if you can’t beat ’em, join ’em” philosophy. We tried waiting out the Sudoku craze — it has to go away at some point, right? — but finally we broke down and embraced the grid fad. Here’s our version of Sudoku, with a genome twist: instead of the numbers 1 through 9, we use letters. When completed, one line of the puzzle will spell a name or term common in this field.